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Literature summary for 3.4.21.104 extracted from

  • Skjoedt, M.O.; Hummelshoj, T.; Palarasah, Y.; Honore, C.; Koch, C.; Skjodt, K.; Garred, P.
    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation (2010), J. Biol. Chem., 285, 8234-8243.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Homo sapiens
-
 ?
-
 ?
complement component C4 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
complement component C4 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Map19 MASP2 isoform 2 Homo sapiens
MASP-2 MASP2 isoform 1 Homo sapiens
MASP2
-
 Homo sapiens
MBL-associated serine protease-2
-
 Homo sapiens
MBL/ficolin-associated serine protease
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MASP-2 is the main initiator of the lectin complement pathway by cleaving C4 and C2 to form the C4b2a complex leading to further downstream complement activation Homo sapiens