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Literature summary for 3.4.19.14 extracted from

  • Shi, Z.; Han, B.; Habib, G.; Matzuk, M.; Lieberman, M.
    Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response (2001), Mol. Cell. Biol., 21, 5389-5395.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Mus musculus
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lung
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 Mus musculus
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spleen
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 Mus musculus
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uterus
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene C4 + H2O
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 Mus musculus leukotriene D4 + L-glutamate
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 ?

Synonyms

Synonyms Comment Organism
gamma-glutamyl leukotrienase
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 Mus musculus
GGL
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 Mus musculus

General Information

General Information Comment Organism
malfunction disruption of gamma-glutamyl leukotrienase (GGL) results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response. In spleen and uterus, deletion of GGL alone abolishes more than 90% of leukotriene D4 synthesis activity. Mice deficient in both gamma-glutamyl transpeptidase (GGT) and GGL have a phenotype similar to the GGT-deficient mice, but about 70% of these mice die before 4 weeks of age, at least 2 months earlier than mice deficient only in GGT. GGL-deficient mice show an attenuation in neutrophil recruitment but not of plasma protein influx Mus musculus