Protein Variants | Comment | Organism |
---|---|---|
additional information | C-terminal deletion of the final four Rrsidues of isoform UCH-L1 (CKAA) leads to increased membrane association and decreased solubility. Deletion disrupts the protein secondary structure, leads to abrogation of substrate binding, increased cell death, and an abnormal intracellular distribution | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | isoform UCHL1 is differently processed in neurons compared with clonal cell lines and farnesylation does not account for the membrane association in neurons | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09936 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | isoform UCH-L1 does not partition to the membrane in the cultured cell lines tested | Homo sapiens | - |
Neuro-2a cell | isoform UCH-L1 does not partition to the membrane in the cultured cell lines tested | Homo sapiens | - |
neuron | isoform UCHL1 is differently processed in neurons compared with clonal cell lines. In primary cultured neurons, a proportion of UCH-L1M does partition to the membrane, but this does not require farnesylation | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
UCH-L1 | - |
Homo sapiens |