Application | Comment | Organism |
---|---|---|
medicine | UCH-L1 is required for maintenance of memory in a passive avoidance test, exploratory behaviour in a novel environment, and a transcription-dependent component of theta-burst stimulation-induced long-term potentiation in area CA1 of the hippocampus | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in gracile axonal dystrophy mice with a spontaneous deletion in the Uch-l1 gene, memory in passive avoidance learning, exploratory behaviour and hippocampal CA1 long-term potentiation are reduced, whereas cyclic AMP response element binding protein phosphorylation is altered | Mus musculus |
additional information | UCHL1-deficient gracile axonal dystrophy, i.e. gad, mice are spontaneous mutants with an in-frame deletion in exons 7 and 8 of Uch-l1. Deletion of the gene encoding UCH-L1 leads to a reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | neuron-specific expression of UCH-L1 | Mus musculus | - |
cornu ammonis | area 1 | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
additional information | UCH-L1 is exclusively expressed in brain and testis | Mus musculus | - |
pyramidal neuron | - |
Mus musculus | - |
testis | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase L1 | - |
Mus musculus |
UCH-L1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | UCH-L1 mediates maintenance of the temporal integrity and persistence of cyclic AMP response element binding protein, CREB, phosphorylation in the brain | Mus musculus |