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Literature summary for 3.4.15.1 extracted from

  • Cheung, H.S.; Cushman, D.W.
    Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca (1973), Biochim. Biophys. Acta, 293, 451-463.
    View publication on PubMed
Search for more literature for 3.4.15.1

Activating Compound

Activating Compound Comment Organism Structure
Cl- activates Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
Pyr-Lys-Trp-Ala-Pro mixed type inhibition Oryctolagus cuniculus
Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro i.e. SQ20881, competitive with angiotensin I and hippuryl-L-His-L-Leu Oryctolagus cuniculus
Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro i.e. SQ20858, competitive with angiotensin I and hippuryl-L-His-L-Leu Oryctolagus cuniculus
snake venom peptide of Bothrops jararaca Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
22
-
-
 Oryctolagus cuniculus

Storage Stability

Storage Stability Organism
5°C, in dilute solution stable for at least 6 months, in acetone powder extracts stable for 2 years Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Oryctolagus cuniculus angiotensin II + His-Leu
-
 ?
hippuryl-His-Leu + H2O
-
 Oryctolagus cuniculus hippuric acid + His-Leu
-
 ?