Application | Comment | Organism |
---|---|---|
medicine | dipeptidyl peptidase IV is a target for the treatment of type 2 diabetes mellitus | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ABT-279 | - |
Homo sapiens | |
AMG-222 | ALS-2-0426 | Homo sapiens | |
ARI-2243 | - |
Homo sapiens | |
ASP8497 | - |
Homo sapiens | |
Bl-1356 | ondero or linagliptin, competitive, reversible, and long-lasting inhibition | Homo sapiens | |
BMS-477118 | saxagliptin, the proprietary name is Onglyza, covalently bound and reversible inhibitor | Homo sapiens | |
BMS-686117 | - |
Homo sapiens | |
CR-14025 | - |
Homo sapiens | |
des-fluoro-sitagliptin | sitagliptin analogue, reversible inhibition | Homo sapiens | |
DP-893 | reversible inhibition | Homo sapiens | |
E-3024 | - |
Homo sapiens | |
ER-319711-15 | - |
Homo sapiens | |
GRC 8200 | melogliptin | Homo sapiens | |
GSK-823093C | denagliptin | Homo sapiens | |
GW-1853 | - |
Homo sapiens | |
IP-10.C8 | - |
Homo sapiens | |
K-579 | reversibile and long-lasting inhibition | Homo sapiens | |
KRP-104 | - |
Homo sapiens | |
LAF-237 | vildagliptin, potent, selective DPP IV inhibitor, the proprietary name is Galvus, covalently bound and reversible inhibitor | Homo sapiens | |
LC-150444 | reversible inhibition | Homo sapiens | |
LY-2463665 | reversible inhibition | Homo sapiens | |
MK-0431 | sitagliptin, potent, selective DPP IV inhibitor, the proprietary name is Januvia, reversible and long-lasting inhibition | Homo sapiens | |
MP-513 | IDDBCP161883 | Homo sapiens | |
NVP DPP728 | slow-binding inhibitor | Homo sapiens | |
P32/P98 | isoleucine thiazolidide DPPIV, reversible inhibition | Homo sapiens | |
PHX-1149 | dutogliptin tartrate, reversible inhibition | Homo sapiens | |
PSN-9301 | P93/01, reversible inhibition, short acting | Homo sapiens | |
PT-630 | - |
Homo sapiens | |
R-1438 | aminomethylpyridine derivate | Homo sapiens | |
R-1579 | carmegliptin, reversible inhibition | Homo sapiens | |
RO-0730699 | - |
Homo sapiens | |
S-40010 | - |
Homo sapiens | |
SK-0403 | - |
Homo sapiens | |
SSR-162369 | reversibile and long-lasting inhibition | Homo sapiens | |
SYR-322 | 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile monobenzoate, also called alogliptin or TAK-322, reversible inhibition | Homo sapiens | |
TAK-100 | - |
Homo sapiens | |
TRC-XXXX | - |
Homo sapiens | |
TS-021 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-microglobulin + H2O | Homo sapiens | - |
? | - |
? | |
aprotinin + H2O | Homo sapiens | - |
? | - |
? | |
beta-casomorphin + H2O | Homo sapiens | - |
? | - |
? | |
bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
enterostatin + H2O | Homo sapiens | - |
? | - |
? | |
gastrin releasing peptide + H2O | Homo sapiens | - |
? | - |
? | |
Glucagon + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide 1 (7-36)-amide + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide 1 (7-37) + H2O | Homo sapiens | - |
? | - |
? | |
glucagon-like peptide 2 (1-33) + H2O | Homo sapiens | - |
? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | Homo sapiens | - |
? | - |
? | |
growth hormone releasing factor + H2O | Homo sapiens | - |
? | - |
? | |
growth hormone releasing hormone (1-29) + H2O | Homo sapiens | - |
? | - |
? | |
growth hormone releasing hormone (1-44) + H2O | Homo sapiens | - |
? | - |
? | |
human chorionic gonadotropin alpha + H2O | Homo sapiens | - |
? | - |
? | |
insulin-like growth factor-1 + H2O | Homo sapiens | - |
? | - |
? | |
interferon-gamma-inducible protein-10 + H2O | Homo sapiens | - |
? | - |
? | |
interleukin 1-beta + H2O | Homo sapiens | - |
? | - |
? | |
interleukin-2 + H2O | Homo sapiens | - |
? | - |
? | |
leutinising hormone alpha chain + H2O | Homo sapiens | - |
? | - |
? | |
macrophage-derived chemokine + H2O | Homo sapiens | - |
? | - |
? | |
monocyte chemotactic protein-1 + H2O | Homo sapiens | - |
? | - |
? | |
monocyte chemotactic protein-2 + H2O | Homo sapiens | - |
? | - |
? | |
neuropeptide Y + H2O | Homo sapiens | - |
? | - |
? | |
peptide YY (1-36) + H2O | Homo sapiens | - |
? | - |
? | |
pro-colipase + H2O | Homo sapiens | - |
? | - |
? | |
prolactin + H2O | Homo sapiens | - |
? | - |
? | |
RANTES protein + H2O | Homo sapiens | - |
? | - |
? | |
stromal cell-derived factor 1alpha + H2O | Homo sapiens | - |
? | - |
? | |
stromal cell-derived factor 1beta + H2O | Homo sapiens | - |
? | - |
? | |
Substance P + H2O | Homo sapiens | - |
? | - |
? | |
thyrotropin + H2O | Homo sapiens | - |
? | - |
? | |
Trypsinogen + H2O | Homo sapiens | - |
? | - |
? | |
trypsinogen pro-peptide + H2O | Homo sapiens | - |
? | - |
? | |
vasostatin-1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
kidney | highly expressed in kidney | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-microglobulin + H2O | - |
Homo sapiens | ? | - |
? | |
aprotinin + H2O | - |
Homo sapiens | ? | - |
? | |
beta-casomorphin + H2O | - |
Homo sapiens | ? | - |
? | |
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
enterostatin + H2O | - |
Homo sapiens | ? | - |
? | |
gastrin releasing peptide + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide 1 (7-36)-amide + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide 1 (7-37) + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide 2 (1-33) + H2O | - |
Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
growth hormone releasing factor + H2O | - |
Homo sapiens | ? | - |
? | |
growth hormone releasing hormone (1-29) + H2O | - |
Homo sapiens | ? | - |
? | |
growth hormone releasing hormone (1-44) + H2O | - |
Homo sapiens | ? | - |
? | |
human chorionic gonadotropin alpha + H2O | - |
Homo sapiens | ? | - |
? | |
insulin-like growth factor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
interferon-gamma-inducible protein-10 + H2O | - |
Homo sapiens | ? | - |
? | |
interleukin 1-beta + H2O | - |
Homo sapiens | ? | - |
? | |
interleukin-2 + H2O | - |
Homo sapiens | ? | - |
? | |
leutinising hormone alpha chain + H2O | - |
Homo sapiens | ? | - |
? | |
macrophage-derived chemokine + H2O | - |
Homo sapiens | ? | - |
? | |
monocyte chemotactic protein-1 + H2O | - |
Homo sapiens | ? | - |
? | |
monocyte chemotactic protein-2 + H2O | - |
Homo sapiens | ? | - |
? | |
neuropeptide Y + H2O | - |
Homo sapiens | ? | - |
? | |
peptide YY (1-36) + H2O | - |
Homo sapiens | ? | - |
? | |
pro-colipase + H2O | - |
Homo sapiens | ? | - |
? | |
prolactin + H2O | - |
Homo sapiens | ? | - |
? | |
RANTES protein + H2O | - |
Homo sapiens | ? | - |
? | |
stromal cell-derived factor 1alpha + H2O | - |
Homo sapiens | ? | - |
? | |
stromal cell-derived factor 1beta + H2O | - |
Homo sapiens | ? | - |
? | |
Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
thyrotropin + H2O | - |
Homo sapiens | ? | - |
? | |
Trypsinogen + H2O | - |
Homo sapiens | ? | - |
? | |
trypsinogen pro-peptide + H2O | - |
Homo sapiens | ? | - |
? | |
vasostatin-1 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase IV | - |
Homo sapiens |
DPP IV | DPP IV has the preference for X-Pro over X-Ala, where X is any amino acid other than L-proline | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000001 | - |
R-1438 | - |
Homo sapiens | |
0.0000006 | - |
BMS-477118 | - |
Homo sapiens | |
0.000001 | - |
ABT-279 | - |
Homo sapiens | |
0.000001 | - |
Bl-1356 | - |
Homo sapiens | |
0.000007 | - |
LY-2463665 | - |
Homo sapiens | |
0.000009 | - |
MK-0431 | - |
Homo sapiens | |
0.000011 | - |
NVP DPP728 | - |
Homo sapiens | |
0.000017 | - |
LAF-237 | - |
Homo sapiens | |
0.000022 | - |
GSK-823093C | - |
Homo sapiens | |
0.00008 | - |
P32/P98 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000001 | - |
- |
Homo sapiens | Bl-1356 | |
0.00000135 | - |
- |
Homo sapiens | MP-513 | |
0.00000161 | - |
- |
Homo sapiens | GRC 8200 | |
0.0000035 | - |
- |
Homo sapiens | LAF-237 | |
0.0000037 | - |
- |
Homo sapiens | BMS-477118 | |
0.0000053 | - |
- |
Homo sapiens | ASP8497 | |
0.000007 | - |
- |
Homo sapiens | SYR-322 | |
0.000018 | - |
- |
Homo sapiens | SSR-162369 | |
0.000018 | - |
- |
Homo sapiens | MK-0431 | |
0.000022 | - |
- |
Homo sapiens | NVP DPP728 | |
0.000034 | - |
- |
Homo sapiens | LY-2463665 | |
0.000089 | - |
- |
Homo sapiens | ER-319711-15 | |
0.00042 | - |
- |
Homo sapiens | P32/P98 |