General Stability | Organism |
---|---|
in presence of stabilizing agents, the enzyme tolerates at least five subsequent freeze/thaw cycles | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lysyl-piperidide | - |
Homo sapiens | |
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
Ala-Pro-p-nitroanilide | 37°C, pH 7.0 | Homo sapiens | |
0.019 | - |
Lys-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.02 | - |
Nle-Nle-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.0223 | - |
His-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.04 | - |
Lys-Ala-p-nitroanilide | 37°C, pH 7.0 | Homo sapiens | |
0.04 | - |
Ala-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.04 | - |
Arg-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.058 | - |
Phe-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.07 | - |
Gly-Pro-p-nitroanilide | 37°C, pH 7-0 | Homo sapiens | |
0.08 | - |
Ser-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.083 | - |
His-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.101 | - |
Asn-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.21 | - |
Gly-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.22 | - |
Tyr-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
0.57 | - |
Lys-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
1.376 | - |
Pro-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
2 * 60000, SDS-PAGE in presence of 2-mercaptoethanol | Homo sapiens |
120000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UHL4 | - |
- |
Purification (Comment) | Organism |
---|---|
purification scheme includes an inhibitor-based affinity chromatographic step | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
seminal plasma | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
70 | - |
substrate: Lys-Ala-p-nitroanilide | Homo sapiens |
Storage Stability | Organism |
---|---|
4°C, -20°C, or -80°C, purified enzyme is stable for at least 4 months in presence of 1 mg/ml bovine serum albumin | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Ala-Pro + p-nitroaniline | - |
? | |
Arg-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Arg-Pro + p-nitroaniline | - |
? | |
Asn-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Asn-Pro + p-nitroaniline | - |
? | |
Gly-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Gly-Pro + p-nitroaniline | - |
? | |
His-Ala-p-nitroanilide + H2O | - |
Homo sapiens | His-Ala + p-nitroaniline | - |
? | |
His-Pro-p-nitroanilide + H2O | - |
Homo sapiens | His-Pro + p-nitroaniline | - |
? | |
Lys-Ala-p-nitroanilide + H2O | - |
Homo sapiens | Lys-Ala + p-nitroaniline | - |
? | |
Lys-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Lys-Pro + p-nitroaniline | - |
? | |
Nle-Nle-p-nitroanilide + H2O | - |
Homo sapiens | Nle-Nle + p-nitroaniline | - |
? | |
Phe-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Phe-Pro + p-nitroaniline | - |
? | |
Pro-Ala-p-nitroanilide + H2O | - |
Homo sapiens | Pro-Ala + p-nitroaniline | - |
? | |
Ser-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Ser-Pro + p-nitroaniline | - |
? | |
Tyr-Ala-p-nitroanilide + H2O | - |
Homo sapiens | Tyr-Ala + p-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 60000, SDS-PAGE in presence of 2-mercaptoethanol | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DPPII | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
2 h, 30% loss of activity without a stabilizer. 10% loss of activity after 4 h in presence of 1 mg/ml bovine serum albumin or 0.1% Tween 20 | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3 | - |
Lys-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
11 | - |
Tyr-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
12.8 | - |
His-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
15.3 | - |
Pro-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
18.4 | - |
Nle-Nle-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
28.4 | - |
His-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
65.8 | - |
Arg-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
66 | - |
Ser-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
67.3 | - |
Gly-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
77.7 | - |
Lys-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
89 | - |
Ala-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
93 | - |
Phe-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
105.4 | - |
Ala-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
116.9 | - |
Ser-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
184.6 | - |
Asn-Pro-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens | |
229.3 | - |
Lys-Ala-p-nitroanilide | 37°C, pH 5.5 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
substrate: Lys-Ala-p-nitroanilide or Ala-Pro-p-nitroanilide | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 6 | pH 4.0: about 50% of maximal activity, pH 6.0: about 40% of maximal activity, substrate: Lys-Ala-p-nitroanilide or Ala-Pro-p-nitroanilide | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000052 | - |
lysyl-piperidide | substrate: Lys-Ala-p-nitroanilide, pH 7.0, 37°C | Homo sapiens | |
0.000063 | - |
lysyl-piperidide | substrate: Ala-Pro-p-nitroanilide, pH 7.0, 37°C | Homo sapiens | |
0.00095 | - |
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride | substrate: Lys-Ala-p-nitroanilide, pH 5.5, 37°C | Homo sapiens | |
0.001 | - |
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride | substrate: Lys-Ala-p-nitroanilide, pH 7.0, 37°C | Homo sapiens | |
0.00105 | - |
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride | substrate: Ala-Pro-p-nitroanilide, pH 7.0, 37°C | Homo sapiens | |
0.00145 | - |
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride | substrate: Ala-Pro-p-nitroanilide, pH 5.5, 37°C | Homo sapiens | |
0.00172 | - |
lysyl-piperidide | substrate: Lys-Ala-p-nitroanilide, pH 5.5, 37°C | Homo sapiens | |
0.00264 | - |
lysyl-piperidide | substrate: Ala-Pro-p-nitroanilide, pH 5., 37°C | Homo sapiens |