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Literature summary for 3.4.14.1 extracted from

  • Latajka, R.; Jewginski, M.; Makowski, M.; Pawe?czak, M.; Huber, T.; Sewald, N.; Kafarski, P.
    Pentapeptides containing two dehydrophenylalanine residues-synthesis, structural studies and evaluation of their activity towards cathepsin C (2008), J. Pept. Sci., 14, 1084-1095.
    View publication on PubMed
Search for more literature for 3.4.14.1

Inhibitors

Inhibitors Comment Organism Structure
Boc-Gly-DELTA(Z)Phe-AbuPO(OMe)2
-
 Homo sapiens
Gly-DELTA(Z)Phe-AlaPO(OEt)2-trifluoroacetic acid
-
 Homo sapiens
Gly-DELTAZPhe-Gly-DELTAEPhe-Gly
-
 Homo sapiens
Gly-DELTAZPhe-Gly-DELTAEPhe-Gly-OMe
-
 Homo sapiens
Gly-DELTAZPhe-Gly-DELTAEPhe-Phe
-
 Homo sapiens
Gly-DELTAZPhe-Gly-DELTAEPhe-Phe-OMe
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin C has a broad substrate specificity being able to hydrolyse out nearly every possible dipeptide unit, with the exception of those containing basic amino acids (Arg or Lys) at N-terminal position or Pro on either side of the scissile bond ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin C has a broad substrate specificity being able to hydrolyse out nearly every possible dipeptide unit, with the exception of those containing basic amino acids (Arg or Lys) at N-terminal position or Pro on either side of the scissile bond Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin C
-
 Homo sapiens
dipeptidyl peptidase I
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
 Gly-DELTAZPhe-Gly-DELTAEPhe-Gly at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens
0.122
-
 Gly-DELTAZPhe-Gly-DELTAEPhe-Phe at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens
0.173
-
 Gly-DELTAZPhe-Gly-DELTAEPhe-Gly-OMe at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens
0.324
-
 Gly-DELTAZPhe-Gly-DELTAEPhe-Phe-OMe at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens
0.681
-
 tert-butyloxycarbonyl-Gly-DELTA(Z)Phe-AbuPO(OMe)2 at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens
1.563
-
 Gly-DELTA(Z)Phe-AlaPO(OEt)2-trifluoroacetic acid at 37°C in acetate buffer (pH 5) containing NaCl (10 mM) Homo sapiens