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Literature summary for 3.4.13.9 extracted from
- Homodimerization via a leucine zipper motif is required for enzymatic activity of quiescent cell proline dipeptidase (2000), J. Biol. Chem., 275, 26994-26999.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the enzyme, tagged with either HA-tag or Myc-tag, in 293T cells, expressio of mutant enzymes in Escherichia coli XL1-Blue | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction and expression of leucine zipper mutants and active site mutants, the former show no remaining activity, while the latter are not catalytically active but are still able to dimerize | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secretion | Homo sapiens | - |
- |
| intracellular | - |
Homo sapiens | 5622 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
2 * 58000, homodimerization via leucine zipper motif is required for activity, the active site is not required for dimerization | Homo sapiens |
| 120000 | 130000 | gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro | the enzyme cleaves N-terminal Xaa-Pro dipeptides from proteins | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Pro-amino-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | alanine + Pro-4-trifluoromethylcoumarin | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 58000, homodimerization via leucine zipper motif is required for activity, the active site is not required for dimerization | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 | Homo sapiens |
| QPP | - |
Homo sapiens |
| quiescent cell proline dipeptidase | - |
Homo sapiens |
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