Literature summary for 3.4.11.22 extracted from

Yousaf, N.; Low, W.; Onipinla, A.; Mein, C.; Caulfield, M.; Munroe, P.; Chernajovsky, Y.
Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines (2015), Clin. Exp. Immunol., 180, 289-304 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NZ08	existence of at least four alternatively spliced variants of ERAP1 mRNA, designated as DELTAExon-11, DELTAExon-13, DELTAExon-14 and DELTAExon-15	-

General Information

General Information	Comment	Organism
physiological function	ERAP1 isoforms may exhibit differential biological properties and inflammatory mediators may play critical roles in modulating ERAP1 expression. Cellular expression of different ERAP1 isoforms varies, and expression of full-length allelic isoform P127-K528 and DELTAExon-11 spliced variant is significantly enhanced when cotransfected with tumor necrosis factor TNF-R1	Homo sapiens

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Release 2023.1 (January 2023)