Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | up-regulation of enzyme expression upon stimulation with interleukin-4 and interleukin-13 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | 92.5% inhibition at 1 mM | Homo sapiens | |
bestatin | 83.7% inhibition at 1 mM | Homo sapiens | |
EDTA | 35.5% inhibition at 5 mM | Homo sapiens | |
additional information | no inhibition by pepstatin, phosphoramidon, and aprotinin | Homo sapiens | |
PMSF | 4.5% inhibition at 1 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | ectoenzyme | Homo sapiens | 9986 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | gingival | Homo sapiens | - |
gingiva | - |
Homo sapiens | - |
leukocyte | polymorphonuclear leukocytes, i.e. PMN, from heparinized venous blood | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glu-Ala-Ala-4-methoxynaphthylamide + H2O | - |
Homo sapiens | ? | - |
? | |
L-Leu-4-nitroanilide + H2O | - |
Homo sapiens | L-Leu + 4-nitroaniline | - |
? | |
additional information | the enzyme expression is regulated on gingival fibroblasts in response to T-cell-derived cytokines, e.g. interleukin-4 and interleukin-13, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase N | - |
Homo sapiens |
CD13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7.6 | assay at, dependent on substrate used | Homo sapiens |