Cloned (Comment) | Organism |
---|---|
GFP fusion protein expressed in muscles of adult CD1 male mice and Drosophila | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | - |
Homo sapiens | |
PAQ-22 | - |
Homo sapiens | |
puromycin | - |
Homo sapiens | |
puromycin aminonucleoside | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-4-methyl-coumaryl-7-amide + H2O | - |
Homo sapiens | Ala + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
puromycin-sensitive aminopeptidase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00007 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | bestatin | |
0.00008 | - |
non-competitive, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | PAQ-22 | |
0.0006 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | puromycin | |
0.0025 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | puromycin aminonucleoside |
General Information | Comment | Organism |
---|---|---|
malfunction | decrease in activity increases the aggregation and toxicity of expanded huntingtin exon 1, overexpression reduces aggregates and toxicity of mutant huntingtin exon 1 | Homo sapiens |
physiological function | suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo, decreases aggregate number in cellular models of neurodegenerative diseases, enhances macroautophagy | Homo sapiens |