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Literature summary for 3.4.11.1 extracted from

  • Shevchenko, K.; Dulov, S.; Andreeva, L.; Nagaev, I.; Shevchenko, V.; Radilov, A.; Myasoedov, N.
    Stability of His-Phe-Arg-Trp-Pro-Gly-Pro to leucine aminopeptidase, carboxypeptidase Y, and rat nasal mucus, blood, and plasma (2016), Russ. J. Bioorg. Chem., 42, 153-161 .
No PubMed abstract available
Search for more literature for 3.4.11.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information dynamics of ACTH-(6-9)-PGP peptide hydrolysis with leucine aminopeptidase and carboxypeptidase Y and reaction kinetics, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus proteolysis of ACTH-(6-9)-PGP peptide in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase ?
-
 ?
additional information Rattus norvegicus Wistar proteolysis of ACTH-(6-9)-PGP peptide in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
nasal mucosa
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
His-Phe-Arg-Trp-Pro-Gly-Pro + H2O ACTH-(6-9)-PGP peptide, proteolysis of the ACTH-(6-9)-PGP is mainly defined by aminopeptidases, the basic metabolite is Trp-Pro-Gly-Pro. After 180 min, Arg-Trp-Pro-Gly-Pro and Trp-Pro-Gly-Pro are generated from Phe-Arg-Trp-Pro-Gly-Pro, and phenylalalnine cleavage proceeds much less efficiently than further cleavage of arginine Rattus norvegicus Trp-Pro-Gly-Pro + Arg-Trp-Pro-Gly-Pro
-
 ?
His-Phe-Arg-Trp-Pro-Gly-Pro + H2O ACTH-(6-9)-PGP peptide, proteolysis of the ACTH-(6-9)-PGP is mainly defined by aminopeptidases, the basic metabolite is Trp-Pro-Gly-Pro. After 180 min, Arg-Trp-Pro-Gly-Pro and Trp-Pro-Gly-Pro are generated from Phe-Arg-Trp-Pro-Gly-Pro, and phenylalalnine cleavage proceeds much less efficiently than further cleavage of arginine Rattus norvegicus Wistar Trp-Pro-Gly-Pro + Arg-Trp-Pro-Gly-Pro
-
 ?
Met-Glu-His-Phe-Pro-Gly-Pro + H2O semax peptide Rattus norvegicus ?
-
 ?
Met-Glu-His-Phe-Pro-Gly-Pro + H2O semax peptide Rattus norvegicus Wistar ?
-
 ?
additional information proteolysis of ACTH-(6-9)-PGP peptide in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase Rattus norvegicus ?
-
 ?
additional information substrate synthesis and application to rats, overview. LC-MS analysis of reaction products after reaction of His-Phe-Arg-Trp-Pro-Gly-Pro with leucine aminopeptidase, carboxypeptidase Y, and rat nasal mucus, blood, and plasma Rattus norvegicus ?
-
 ?
additional information proteolysis of ACTH-(6-9)-PGP peptide in rat blood and plasma occurs mainly under the effect of enzymes whose action is similar to leucine aminopeptidase Rattus norvegicus Wistar ?
-
 ?
additional information substrate synthesis and application to rats, overview. LC-MS analysis of reaction products after reaction of His-Phe-Arg-Trp-Pro-Gly-Pro with leucine aminopeptidase, carboxypeptidase Y, and rat nasal mucus, blood, and plasma Rattus norvegicus Wistar ?
-
 ?

Synonyms

Synonyms Comment Organism
leucine aminopeptidase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus