Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | slow-binding, competitive | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00887 | - |
4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate | pH 7.4, 25°C | Sus scrofa | |
0.065 | - |
N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide | pH not specified in the publication, temperature not specified in the publication | Sus scrofa | |
3 | - |
L-leucine-4-nitroanilide | pH not specified in the publication, temperature not specified in the publication | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Sus scrofa | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
commercial preparation | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3.9 | - |
L-leucine-4-nitroanilide, pH not specified in the publication, temperature not specified in the publication | Sus scrofa |
6.64 | - |
4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate, pH 7.4, 25°C | Sus scrofa |
7.7 | - |
N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide, pH not specified in the publication, temperature not specified in the publication | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate + H2O | - |
Sus scrofa | L-leucine + 4-[(E)-2-(4-aminophenyl)ethenyl-3-cyano-5,5-dimethylfuran-2(5H)-ylidene]propanedinitrile | - |
? | |
L-leucine-4-nitroanilide + H2O | - |
Sus scrofa | L-leucine + 4-nitroaniline | - |
? | |
N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide + H2O | - |
Sus scrofa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
leucine aminopeptidase | - |
Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00441 | - |
substrate 4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate, pH 7.4, 25°C | Sus scrofa | bestatin | |
0.007 | - |
substrate N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide, pH not specified in the publication, temperature not specified in the publication | Sus scrofa | bestatin | |
0.025 | - |
substrate L-leucine-4-nitroanilide, pH not specified in the publication, temperature not specified in the publication | Sus scrofa | bestatin |