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Literature summary for 3.3.2.10 extracted from

  • Koeners, M.; Wesseling, S.; Ulu, A.; Sepúlveda, R.; Morisseau, C.; Braam, B.; Hammock, B.; Joles, J.
    Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats (2011), Am. J. Physiol. Endocrinol. Metab., 300, 691-698.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine inhibition of soluble epoxide hydrolase by orally active inhibitor 12-(3-adamantan-1-yl-ureido)-dodecanoic acid is effective in persistently reducing blood pressure in female spontaneously hypertensive rats when 12-(3-adamantan-1-yl-ureido)-dodecanoic acid is applied during the perinatal phase. This is accompanied by marked increases in major renal arachidonic acid epoxides and decreases in renal lipoxygenase products of arachidonic acid. Early inhibition of SEH induces a delayed increase in renal 5-HETE at 24 weeks, in contrast to a decrease at 2 weeks. Inhibition of SEH in female spontaneously hypertensive rats from 8 to 12 weeks does not reduce blood but causes profound decreases in renal 15(S)-HETrE, LTB4, TBX2, 5-HETE, and 20-HETE and increases in TriHOMEs. In male spontaneously hypertensive rats, blood pressure reduction after perinatal AUDA is transient Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
12-(3-adamantan-1-yl-ureido)-dodecanoic acid orally active inhibitor. Inhibition of soluble epoxide hydrolase is effective in persistently reducing blood pressure in female spontaneously hypertensive rats when 12-(3-adamantan-1-yl-ureido)-dodecanoic acid is applied during the perinatal phase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 spontaneously hypertensive rats
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
SEH
-
 Rattus norvegicus