Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a target for inhibition in therapy of disorders resulting from hypertension and vascular inflammation | Mus musculus |
pharmacology | the enzyme is a target for inhibition in therapy of disorders resulting from hypertension and vascular inflammation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-cyclohexyl-3-dodecylurea | i.e. 1-cyclohexyl-3-dodecyl-urea | Homo sapiens | |
1-cyclohexyl-3-dodecylurea | i.e. 1-cyclohexyl-3-dodecyl-urea | Mus musculus | |
1-cyclohexyl-3-ethylurea | i.e. N-cyclohexyl-N'-ethylurea | Homo sapiens | |
1-cyclohexyl-3-ethylurea | i.e. N-cyclohexyl-N'-ethylurea | Mus musculus | |
1-cyclohexyl-3-hexylurea | i.e. N-cyclohexyl-N'-hexylurea | Homo sapiens | |
1-cyclohexyl-3-hexylurea | i.e. N-cyclohexyl-N'-hexylurea | Mus musculus | |
AUDA | i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid | Homo sapiens | |
AUDA | i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid | Mus musculus | |
additional information | IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates | Homo sapiens | |
additional information | IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates | Mus musculus | |
N,N-dicyclohexylurea | i.e. N,N-dicyclohexylurea | Homo sapiens | |
N,N-dicyclohexylurea | i.e. N,N-dicyclohexylurea | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.01 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate | Mus musculus |
0.12 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate | Homo sapiens |
0.13 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate | Mus musculus |
0.21 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate | Mus musculus |
0.26 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate | Mus musculus |
0.28 | - |
purified recombinant enzyme, substrate cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate | Mus musculus |
0.36 | - |
purified recombinant enzyme, substrate [3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate | Homo sapiens |
0.38 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate | Homo sapiens |
0.41 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate | Homo sapiens |
0.53 | - |
purified recombinant enzyme, substrate cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate | Homo sapiens |
0.71 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate | Homo sapiens |
0.78 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate | Mus musculus |
0.86 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate | Mus musculus |
1.02 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate | Homo sapiens |
1.04 | - |
purified recombinant enzyme, substrate [3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate | Mus musculus |
2.69 | - |
purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O | - |
Mus musculus | ? | - |
? | |
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O | - |
Homo sapiens | ? | - |
? | |
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O | preferred fluorogenic substrate | Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
additional information | reaction mechanism with flurogenic substrates | Mus musculus | ? | - |
? | |
additional information | reaction mechanism with flurogenic substrates | Homo sapiens | ? | - |
? | |
trans-diphenylpropene oxide + H2O | - |
Mus musculus | ? | - |
? | |
trans-diphenylpropene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O | - |
Mus musculus | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? | |
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O | - |
Homo sapiens | 6-methoxy-2-naphthaldehyde + CN- + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |
SEH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Mus musculus |
7 | - |
assay at | Homo sapiens |