BRENDA - Enzyme Database
show all sequences of 3.2.2.7

Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenine

Nolan, L.L.; Kidder, G.W.; Antimicrob. Agents Chemother. 17, 567-571 (1980)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
6-Methylaminopurine
growth inhibition by addition to culture media
Crithidia fasciculata
6-Methylaminopurine
growth inhibition by addition to culture media
Trypanosoma cruzi
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
adenosine + H2O
Crithidia fasciculata
component of the purine salvage pathway
6-aminopurine + D-ribofuranose
-
Crithidia fasciculata
?
adenosine + H2O
Trypanosoma cruzi
component of the purine salvage pathway
6-aminopurine + D-ribofuranose
-
Trypanosoma cruzi
?
adenosine + H2O
Crithidia fasciculata
6-aminopurine-9-beta-D-ribofuranoside
6-aminopurine + D-ribofuranose
-
Crithidia fasciculata
?
adenosine + H2O
Trypanosoma cruzi
6-aminopurine-9-beta-D-ribofuranoside
6-aminopurine + D-ribofuranose
-
Trypanosoma cruzi
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Crithidia fasciculata
-
-
-
no activity in Leishmania braziliensis
-
-
-
no activity in Leishmania donovani
-
-
-
no activity in Leishmania mexicana
-
-
-
no activity in Leishmania tarentolae
-
-
-
Trypanosoma cruzi
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
growth inhibition by 6-methylaminopurine
Crithidia fasciculata
-
cell culture
growth inhibition by 6-methylaminopurine
Trypanosoma cruzi
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
adenosine + H2O
component of the purine salvage pathway
137108
Crithidia fasciculata
6-aminopurine + D-ribofuranose
-
137108
Crithidia fasciculata
?
adenosine + H2O
component of the purine salvage pathway
137108
Trypanosoma cruzi
6-aminopurine + D-ribofuranose
-
137108
Trypanosoma cruzi
?
adenosine + H2O
6-aminopurine-9-beta-D-ribofuranoside
137108
Crithidia fasciculata
6-aminopurine + D-ribofuranose
-
137108
Crithidia fasciculata
?
adenosine + H2O
6-aminopurine-9-beta-D-ribofuranoside
137108
Trypanosoma cruzi
6-aminopurine + D-ribofuranose
-
137108
Trypanosoma cruzi
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
6-Methylaminopurine
growth inhibition by addition to culture media
Crithidia fasciculata
6-Methylaminopurine
growth inhibition by addition to culture media
Trypanosoma cruzi
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
adenosine + H2O
Crithidia fasciculata
component of the purine salvage pathway
6-aminopurine + D-ribofuranose
-
Crithidia fasciculata
?
adenosine + H2O
Trypanosoma cruzi
component of the purine salvage pathway
6-aminopurine + D-ribofuranose
-
Trypanosoma cruzi
?
adenosine + H2O
Crithidia fasciculata
6-aminopurine-9-beta-D-ribofuranoside
6-aminopurine + D-ribofuranose
-
Crithidia fasciculata
?
adenosine + H2O
Trypanosoma cruzi
6-aminopurine-9-beta-D-ribofuranoside
6-aminopurine + D-ribofuranose
-
Trypanosoma cruzi
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
growth inhibition by 6-methylaminopurine
Crithidia fasciculata
-
cell culture
growth inhibition by 6-methylaminopurine
Trypanosoma cruzi
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
adenosine + H2O
component of the purine salvage pathway
137108
Crithidia fasciculata
6-aminopurine + D-ribofuranose
-
137108
Crithidia fasciculata
?
adenosine + H2O
component of the purine salvage pathway
137108
Trypanosoma cruzi
6-aminopurine + D-ribofuranose
-
137108
Trypanosoma cruzi
?
adenosine + H2O
6-aminopurine-9-beta-D-ribofuranoside
137108
Crithidia fasciculata
6-aminopurine + D-ribofuranose
-
137108
Crithidia fasciculata
?
adenosine + H2O
6-aminopurine-9-beta-D-ribofuranoside
137108
Trypanosoma cruzi
6-aminopurine + D-ribofuranose
-
137108
Trypanosoma cruzi
?
Other publictions for EC 3.2.2.7
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752110
Thicklin
Purification of a non-specifi ...
Pisum sativum
Protein Expr. Purif.
154
140-146
2019
-
-
-
-
-
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-
2
-
-
-
-
-
1
-
-
1
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1
1
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13
1
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1
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2
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1
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1
1
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13
1
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-
1
-
-
-
-
-
-
-
-
-
700741
Jung
Uridine-ribohydrolase is a key ...
Arabidopsis thaliana
Plant Cell
21
876-891
2009
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-
1
-
1
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2
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1
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5
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2
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1
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1
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5
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2
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710272
Mach
-
Uridine ribohydrolase and the ...
Arabidopsis thaliana
Plant Cell
21
0000
2009
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-
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-
-
1
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1
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5
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1
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1
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5
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681129
Yin
Involvement of rapid nucleotid ...
Catharanthus roseus
J. Exp. Bot.
58
1025-1033
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676653
Katahira
Role of adenosine salvage in w ...
Solanum tuberosum
Plant Physiol. Biochem.
44
551-555
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
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-
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1
-
-
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-
-
-
-
-
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-
-
-
682289
Shimano
Effect of long-term phosphate ...
Catharanthus roseus
Phytochemistry
67
132-141
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
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1
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1
-
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-
-
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-
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-
-
-
-
-
-
-
670512
Campos
Purification and characterisat ...
Coffea arabica
Phytochemistry
66
147-151
2005
-
-
-
-
-
-
-
1
-
-
2
-
-
2
-
-
1
-
-
1
1
-
1
1
-
-
-
-
1
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-
1
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2
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1
-
1
1
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
657086
Ashihara
-
Comparison of adenosine metabo ...
Avicennia marina, Bruguiera gymnorhiza, Kandelia candel, Lumnitzera racemosa, Pemphis acidula, Rhizophora stylosa, Sonneratia alba
Plant Physiol. Biochem.
41
133-139
2003
-
-
-
-
-
-
-
-
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-
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7
-
7
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7
-
-
14
-
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7
-
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7
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655545
Koshiishi
A new caffeine biosynthetic pa ...
Camellia sinensis
FEBS Lett.
499
50-54
2001
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
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-
-
1
-
-
1
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-
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-
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1
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1
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1
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
137099
Abusamhadneh
-
Isolation and characterization ...
Lupinus luteus
Plant Sci.
153
25-32
2000
-
-
-
-
-
1
-
1
-
-
1
4
1
1
-
-
1
-
-
1
1
-
10
1
-
-
-
1
1
-
-
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-
-
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-
-
-
-
-
-
1
-
-
-
1
-
-
1
4
1
-
-
1
-
1
1
-
10
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
137100
Edwards
-
S-adenosyl-L-methionine metabo ...
Medicago sativa
Phytochemistry
43
1163-1169
1996
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
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-
2
-
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-
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4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
137101
Negishi
-
N-methyl nucleosidase from tea ...
Camellia sinensis
Agric. Biol. Chem.
52
169-175
1988
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
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1
1
-
3
-
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-
2
-
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1
-
1
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
137102
Lee
-
Nucleic acid degrading enzymes ...
Hordeum vulgare
J. Am. Soc. Brew. Chem.
44
86-90
1986
-
-
-
-
-
1
4
1
-
-
1
3
-
1
-
-
1
-
-
1
1
1
3
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
1
-
-
1
3
-
-
-
1
-
1
1
1
3
-
1
1
1
-
1
-
-
-
-
-
-
-
-
-
137103
Burch
-
Purification and properties of ...
Solanum lycopersicum
J. Plant Physiol.
125
267-273
1986
-
-
-
-
-
-
4
3
-
-
1
3
-
1
-
-
1
-
-
2
-
-
3
-
-
-
-
-
2
-
-
-
-
-
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4
-
3
-
-
1
3
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-
1
-
2
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
137104
Leszczynska
-
Comparative studies on adenosi ...
Acacia dealbata, Fraxinus excelsior, Larix decidua, no activity in Ceratodon purpureus, no activity in Equisetum arvense, no activity in Populus alba, Tilia cordata, Ulmus carpinifolia
Ann. Bot.
54
847-849
1984
-
-
-
-
-
-
-
-
-
-
-
5
-
8
-
-
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-
-
5
-
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5
-
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5
-
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5
-
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5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
137051
Le Floc'h
-
The purine nucleosidases of Je ...
Helianthus tuberosus
Phytochemistry
20
2127-2129
1981
-
-
-
-
-
1
-
1
-
-
-
1
-
1
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1
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1
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1
1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
137106
Schneider
-
Stabilization of enzymes in Se ...
Hordeum vulgare
J. Appl. Biochem.
3
135-146
1981
-
-
-
-
-
-
-
-
-
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-
1
-
1
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1
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1
1
1
1
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1
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1
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1
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1
1
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
137107
Chen
Metabolism of cytokinin: Derib ...
Triticum aestivum
Plant Physiol.
68
1020-1023
1981
-
-
-
-
-
-
5
2
-
-
1
2
-
3
-
-
1
-
-
2
1
1
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
2
-
-
1
2
-
-
-
1
-
2
1
1
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
137108
Nolan
Inhibition of growth and purin ...
Crithidia fasciculata, no activity in Leishmania braziliensis, no activity in Leishmania donovani, no activity in Leishmania mexicana, no activity in Leishmania tarentolae, Trypanosoma cruzi
Antimicrob. Agents Chemother.
17
567-571
1980
-
-
-
-
-
-
2
-
-
-
-
4
-
12
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
137109
Imagawa
-
Purification and properties of ...
Camellia sinensis
Agric. Biol. Chem.
43
2337-2342
1979
-
-
-
-
-
-
1
-
-
-
1
4
-
1
-
-
1
1
-
1
3
1
5
-
2
-
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
4
-
-
-
1
-
1
3
1
5
-
2
-
1
-
2
-
1
-
-
-
-
-
-
-
137110
Guranowski
Adenosylhomocysteinase and ade ...
Lupinus luteus
Planta
139
245-247
1978
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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Purification and characterizat ...
Hordeum vulgare
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1977
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137112
Clark
-
Purification and properties of ...
Solanum tuberosum
Phytochemistry
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1972
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Mazelis
An adenosine hydrolase from Br ...
Brassica oleracea
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