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Literature summary for 3.2.2.29 extracted from
- Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts (2014), Free Radic. Biol. Med., 76, 136-146.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli Bl21-CodonPlus (DE3)-RP cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| glutathione Sepharose column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine-mismatched double-stranded DNA + H2O | the enzyme is capable of removing thymine that has mispaired with 3,N4-ethenocytosine, butanone-ethenocytosine, butanone-ethenoguanine, heptanone-ethenocytosine, or heptanone-ethenoguanine in vitro | Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TDG | - |
Homo sapiens |
| thymine DNA glycosylase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme-knockdown cells exhibit higher resistance to cell death caused by the induction of etheno-DNA adducts, lower repair activityfor 3,N4-ethenocytosine, and a modest acceleration of mutations caused by 3,N4-ethenocytosine,compared with the rate in control cells | Homo sapiens |
| physiological function | the enzyme shows repair activities toward etheno-DNA adducts | Homo sapiens |
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Release 2023.1 (January 2023)
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