Literature summary for 3.2.2.23 extracted from

Le Meur, R.; Culard, F.; Nadan, V.; Goffinont, S.; Coste, F.; Guerin, M.; Loth, K.; Landon, C.; Castaing, B.
The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase (2015), Biochem. J., 471, 13-23 .

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P05523	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
53mer containing 8-oxoguanine + H2O	-	Escherichia coli	53mer with an abasic site + 8-oxoguanine	-	?

General Information

General Information	Comment	Organism
physiological function	nucleoid-associated protein HU enhances the 8-oxoguanine-DNA glycosylase activity of Fpg by facilitating the release of the enzyme from its final DNA product. The displacement of Fpg from its end-DNA product by HU is an active mechanism in which HU recognizes the product when it is still bound by Fpg. The two proteins form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of single-strand breaks by HU	Escherichia coli

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Release 2023.1 (January 2023)