Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000024 | - |
1,N6-ethenoadenine residues in alkylated DNA | pH 7.5, 37°C, excision of 1, N6-ethenoadenine | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alkylated DNA + H2O | Homo sapiens | - |
3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,N6-ethenoadenine residues in alkylated DNA + H2O | - |
Homo sapiens | ethenoadenine + DNA | - |
? | |
alkylated DNA + H2O | - |
Homo sapiens | 3-methyladenine + 7-methylguanine + O2-methylthymine + O2-methylcytosine + DNA | - |
? | |
additional information | removes N-alkylpurine damage, unrepaired DNA damage leads to carcinogenesis, cell death, and aging, also releases 1,N6-ethenoadenine | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alkylpurine-DNA-N-glycosylase | - |
Homo sapiens |
ANPG | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000833 | - |
1,N6-ethenoadenine residues in alkylated DNA | pH 7.5, 37°C, excision of1, N6-ethenoadenine | Homo sapiens |