Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | Homo sapiens | human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12891 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | the enzyme translocates to the surface upon activation to function in extracellular matrix degradation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | - |
Homo sapiens | ? | - |
? | |
hyaluronan + H2O | human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hyal2 | - |
Homo sapiens |
hyaluronidase-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | patients with inflammatory bowel disease have lower platelet HYAL2 levels and activity than healthy controls | Homo sapiens |
physiological function | human platelets degrade the proinflammatory matrix hyaluronan through the activity of HYAL2 and platelet activation causes the immediate translocation of HYAL2 from a distinct population of alpha-granules to platelet surfaces where it exerts its catalytic activity | Homo sapiens |