Application | Comment | Organism |
---|---|---|
diagnostics | increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, in vitro translation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | Homo sapiens | complete degradation, absolutely specific for | ? | - |
? | |
additional information | Homo sapiens | alternative splicing controls the cellular expression of enzymatically active hyaluronidase | ? | - |
? | |
additional information | Homo sapiens | increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
wild-type isozyme HYAL1 | - |
Homo sapiens | O43820 | isozyme splice variant HYAL3v1 | - |
Homo sapiens | O43820 | isozyme splice variant HYAL3v2 | - |
Homo sapiens | O43820 | isozyme splice variant HYAL3v3 | - |
Homo sapiens | O43820 | wild-type isozyme HYAL3wt | - |
Homo sapiens | Q12794 | isozyme splice variant HYAL1v1 | - |
Homo sapiens | Q12794 | isozyme splice variant HYAL1v2 | - |
Homo sapiens | Q12794 | isozyme splice variant HYAL1v3 | - |
Homo sapiens | Q12794 | isozyme splice variant HYAL1v4 | - |
Homo sapiens | Q12794 | isozyme splice variant HYAL1v5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | tissue and cells | Homo sapiens | - |
bladder carcinoma cell | - |
Homo sapiens | - |
bladder tumour cell | G1 tumour tissue | Homo sapiens | - |
bladder tumour cell | G2 and G3 tumour tissues, and invasive tumour cells | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
additional information | tissue distribution | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
prostate carcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronan + H2O | - |
Homo sapiens | ? | - |
? | |
hyaluronan + H2O | complete degradation, absolutely specific for | Homo sapiens | ? | - |
? | |
hyaluronan + H2O | wild-type isozyme HYAL1 sequence, amino acid residues 301-330, is critical for hyaluronidase activity | Homo sapiens | ? | - |
? | |
additional information | the splice variant is enzymatically inactive | Homo sapiens | ? | - |
? | |
additional information | alternative splicing controls the cellular expression of enzymatically active hyaluronidase | Homo sapiens | ? | - |
? | |
additional information | increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HYAL1 | - |
Homo sapiens |
HYAL3 | - |
Homo sapiens |
hyaluronidase | - |
Homo sapiens |