Literature summary for 3.2.1.166 extracted from

Miller, J.D.; Clabaugh, S.E.; Smith, D.R.; Stevens, R.B.; Wrenshall, L.E.
Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase (2012), Immunol. Cell Biol., 90, 159-167.

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Inhibitors

Inhibitors	Comment	Organism	Structure
PI-88	competitive inhibitor of heparanase	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
51000	-	x * 51000, active enzyme form, SDS-PAGE	Homo sapiens
65000	-	x * 65000, inactive proenzyme, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood vessel	-	Homo sapiens	-
CTLL-2 cell	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 51000, active enzyme form, SDS-PAGE	Homo sapiens
?	x * 65000, inactive proenzyme, SDS-PAGE	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	biologically active interleukin-2 is released from the surface of endothelial cells and smooth muscle cells lining blood vessels by heparanase	Homo sapiens

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Release 2023.1 (January 2023)