Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deoxyfuconojirimycin | competitive | Tannerella forsythia | |
fucose | competitive | Tannerella forsythia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.67 | - |
4-nitrophenyl alpha-L-fucopyranoside | 22°C, pH 9.0 | Tannerella forsythia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | following knock-out of the Tffuc1 gene and analyzing biofilm formation and cell invasion/adhesion of the mutant in comparison to the wild-type, it is most likely that the enzyme does not act extracellularly | Tannerella forsythia | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51000 | - |
- |
Tannerella forsythia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tannerella forsythia | G8UMQ6 | - |
- |
Tannerella forsythia ATCC 43037 | G8UMQ6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-fucosyl-N-acetyllactosamine + H2O | - |
Tannerella forsythia | alpha-L-fucose + ? | - |
? | |
2'-fucosyl-N-acetyllactosamine + H2O | - |
Tannerella forsythia ATCC 43037 | alpha-L-fucose + ? | - |
? | |
2-fucosyllactose + H2O | - |
Tannerella forsythia | alpha-L-fucose + lactose | - |
? | |
2-fucosyllactose + H2O | - |
Tannerella forsythia ATCC 43037 | alpha-L-fucose + lactose | - |
? | |
4-nitrophenyl alpha-L-fucopyranoside + H2O | - |
Tannerella forsythia | 4-nitrophenol + alpha-L-fucopyranose | - |
? | |
alpha-L-Fuc-(1->6)-beta-D-GlcNAc + H2O | - |
Tannerella forsythia | alpha-L-fucose + N-acetyl-D-glucosamine | - |
? | |
additional information | the enzyme is a alpha(1,2)-fucosidase that also possesses alpha(1,6) specificity on small unbranched substrates. It is active on mucin after sialidase-catalyzed removal of terminal sialic acid residues and also removes fucose from blood group H. The alpha(1,3) and alpha(1,4) linkages are not cleaved on 3-fucosyllactose and the Lewis A trisaccharide, respectively. The enzyme is also inactive on the substrate alpha-L-Fuc-(1,4)-beta-D-Gal | Tannerella forsythia | ? | - |
? | |
additional information | the enzyme is a alpha(1,2)-fucosidase that also possesses alpha(1,6) specificity on small unbranched substrates. It is active on mucin after sialidase-catalyzed removal of terminal sialic acid residues and also removes fucose from blood group H. The alpha(1,3) and alpha(1,4) linkages are not cleaved on 3-fucosyllactose and the Lewis A trisaccharide, respectively. The enzyme is also inactive on the substrate alpha-L-Fuc-(1,4)-beta-D-Gal | Tannerella forsythia ATCC 43037 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
bfo_2737 | - |
Tannerella forsythia |
TfFuc1 | - |
Tannerella forsythia |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Tannerella forsythia |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
8 | 10.2 | pH 8.0: about 70% of maximal activity, pH 10.2: about 40% of maximal activity | Tannerella forsythia |
General Information | Comment | Organism |
---|---|---|
physiological function | the biological role of the enzyme in the metabolism of short oligosaccharides in the periplasm, thereby indirectly contributing to the virulence of this organism | Tannerella forsythia |