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Literature summary for 3.2.1.124 extracted from

  • Stead, C.; Zhao, J.; Raetz, C.; Trent, M.
    Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface (2010), Mol. Microbiol., 78, 837-852.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.124

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli HMS174 cells Helicobacter pylori

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-dephosphorylated Kdo2-lipid A + H2O
-
 Helicobacter pylori ?
-
 ?
Kdo2-lipid A + H2O
-
 Helicobacter pylori ?
-
 ?

Synonyms

Synonyms Comment Organism
3-deoxy-D-manno-octulosonic acid hydrolase
-
 Helicobacter pylori
Hp0580
-
 Helicobacter pylori
Kdo hydrolase
-
 Helicobacter pylori

General Information

General Information Comment Organism
malfunction inactivation of Kdo hydrolase activity produces two phenotypes associated with cationic antimicrobial peptide resistance and O-antigen expression. Kdo hydrolase mutants are highly sensitive to polymyxin B. Production of a fully extended O-antigen is also diminished in a Kdo hydrolase mutant, with a consequent increase in core-lipid A Helicobacter pylori
physiological function Kdo hydrolase plays a role in the maintenance of the bacterial surface. Kdo hydrolase activity modulates O-antigen expression Helicobacter pylori