Application | Comment | Organism |
---|---|---|
medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Mus musculus |
medicine | enzyme deficiency causes congenital dyserythropoietic anemia with splenomegaly and various additional abnormalities and complications | Homo sapiens |
medicine | reduced expression of Man II in the autosomal genetic HEMPAS disease, i.e. hereditary erythroblastic multinuclearity associated with positive acidified serum | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
Golgi mannosidase II gene is located on chromosome 5q21, Golgi mannosidase IIx on chromosome 15q25 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mutants without GlcNAc(Man)5(GlcNAc)2 activity, Golgi mannosidase II-null mice phenotype | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-Dideoxy-1,4-imino-D-mannitol | - |
Homo sapiens | |
1,4-Dideoxy-1,4-imino-D-mannitol | - |
Mus musculus | |
1,4-Dideoxy-1,4-imino-D-mannitol | - |
Rattus norvegicus | |
swainsonine | - |
Drosophila melanogaster | |
swainsonine | - |
Homo sapiens | |
swainsonine | - |
Mus musculus | |
swainsonine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Drosophila melanogaster | 5794 | - |
Golgi apparatus | - |
Mus musculus | 5794 | - |
Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Rattus norvegicus | |
Zn2+ | active site coordination to Zn2+ | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Drosophila melanogaster | - |
? | - |
? | |
additional information | Rattus norvegicus | - |
? | - |
? | |
additional information | Mus musculus | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? | |
additional information | Homo sapiens | involved in trimming reactions in N-glycan maturation in the Golgi complex | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | rat | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl alpha-D-mannoside + H2O | - |
Drosophila melanogaster | 4-nitrophenol + alpha-D-mannose | - |
? | |
4-nitrophenyl alpha-D-mannoside + H2O | - |
Homo sapiens | 4-nitrophenol + alpha-D-mannose | - |
? | |
4-nitrophenyl alpha-D-mannoside + H2O | rat | Rattus norvegicus | 4-nitrophenol + alpha-D-mannose | - |
? | |
D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Mus musculus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Homo sapiens | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
D-Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O | - |
Rattus norvegicus | D-Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + alpha-D-mannose | - |
? | |
additional information | - |
Drosophila melanogaster | ? | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Mus musculus | ? | - |
? | |
additional information | involved in trimming reactions in N-glycan maturation in the Golgi complex | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Mus musculus |
Golgi mannosidase IIx | close homolog to Golgi mannosidase II with different substrate specificity | Homo sapiens |
More | member of glycosyl hydrolase family 38 | Drosophila melanogaster |
More | member of glycosyl hydrolase family 38 | Mus musculus |
More | member of glycosyl hydrolase family 38 | Homo sapiens |