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Literature summary for 3.1.6.2 extracted from

  • Kurogi, K.; Yoshihama, M.; Williams, F.E.; Kenmochi, N.; Sakakibara, Y.; Suiko, M.; Liu, M.C.
    Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase (2019), J. Steroid Biochem. Mol. Biol., 185, 110-117 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.6.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cell Homo sapiens
expression in COS-7 cell Danio rerio

Inhibitors

Inhibitors Comment Organism Structure
EMATE
-
 Danio rerio
Fe2+ 10 mM, about 50% of initial activity Danio rerio
Fe2+ 10 mM, about 40% of initial activity Homo sapiens
STX64 0.0001 mM, 88.3% inhibition Danio rerio
Zn2+ 10 mM, loss of activity Danio rerio
Zn2+ 10 mM, loss of activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00018
-
 pregnenolone 3-sulfate pH 7.0, 28°C Danio rerio
0.00025
-
 pregnenolone 3-sulfate pH 7.0, 37°C Danio rerio
0.00062
-
 cholesterol 3-sulfate pH 7.0, 28°C Danio rerio
0.001
-
 cholesterol 3-sulfate pH 7.0, 37°C Danio rerio
0.0018
-
 pregnenolone 3-sulfate pH 7.0, 37°C Homo sapiens
0.0019
-
 17beta-estradiol sulfate pH 7.0, 37°C Danio rerio
0.0021
-
 17beta-estradiol sulfate pH 7.0, 28°C Danio rerio
0.0029
-
 dehydroepiandrosterone 3-sulfate pH 7.0, 37°C Homo sapiens
0.0034
-
 Estrone 3-sulfate pH 7.0, 37°C Danio rerio
0.0043
-
 17beta-estradiol sulfate pH 7.0, 37°C Homo sapiens
0.0043
-
 Estrone 3-sulfate pH 7.0, 28°C Danio rerio
0.0051
-
 Estrone 3-sulfate pH 7.0, 37°C Homo sapiens
0.0057
-
 cholesterol 3-sulfate pH 7.0, 37°C Homo sapiens
0.0157
-
 dehydroepiandrosterone 3-sulfate pH 7.0, 37°C Danio rerio
0.0194
-
 dehydroepiandrosterone 3-sulfate pH 7.0, 28°C Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Danio rerio
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 10 mM, about 120% of initial activity Homo sapiens
Ca2+ 10 mM, about 130% of initial activity Danio rerio
Mg2+ 10 mM, about 120% of initial activity Homo sapiens
Mg2+ 10 mM, about 125% of initial activity Danio rerio
Mn2+ 10 mM, about 115% of initial activity Homo sapiens
Mn2+ 10 mM, about 150% of initial activity Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio F1QB82 isoform S
-
Homo sapiens P08842
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol sulfate + H2O
-
 Homo sapiens 17beta-estradiol + sulfate
-
 ?
17beta-estradiol sulfate + H2O
-
 Danio rerio 17beta-estradiol + sulfate
-
 ?
cholesterol 3-sulfate + H2O
-
 Homo sapiens cholesterol + sulfate
-
 ?
cholesterol 3-sulfate + H2O
-
 Danio rerio cholesterol + sulfate
-
 ?
dehydroepiandrosterone 3-sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
dehydroepiandrosterone 3-sulfate + H2O
-
 Danio rerio dehydroepiandrosterone + sulfate
-
 ?
estrone 3-sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
estrone 3-sulfate + H2O
-
 Danio rerio estrone + sulfate
-
 ?
pregnenolone 3-sulfate + H2O
-
 Homo sapiens pregnenolone + sulfate
-
 ?
pregnenolone 3-sulfate + H2O
-
 Danio rerio pregnenolone + sulfate
-
 ?