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Literature summary for 3.1.4.35 extracted from
- Carboxyamidotriazole A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases (2015), Eur. J. Pharmacol., 746, 14-21 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methylxanthine | - |
Mus musculus |  |
| 3-isobutyl-1-methylxanthine | - |
Rattus norvegicus | |
| carboxyamidotriazole | non-selective inhibition | Mus musculus | |
| carboxyamidotriazole | non-selective inhibition | Rattus norvegicus | |
| sildenafil | - |
Mus musculus | |
| sildenafil | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | Mus musculus | - |
5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | Rattus norvegicus | - |
5'-GMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| L-1210 cell | - |
Mus musculus | - |
| Lewis lung carcinoma cell | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| lymphocytic leukemia cell | - |
Mus musculus | - |
| peritoneal macrophage | - |
Mus musculus | - |
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Mus musculus | 5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-PDE | - |
Mus musculus |
| cGMP-PDE | - |
Rattus norvegicus |
| cGMP-phosphodiesterase | - |
Mus musculus |
| cGMP-phosphodiesterase | - |
Rattus norvegicus |
| guanosine 3',5'-cyclicmonophosphate-specific PDE | - |
Mus musculus |
| guanosine 3',5'-cyclicmonophosphate-specific PDE | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000193 | - |
enzyme from lung, at pH 8.0 and 30°C | Mus musculus | sildenafil | |
| 0.000429 | - |
enzyme from lung, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
| 0.00127 | - |
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C | Mus musculus | sildenafil | |
| 0.00185 | - |
enzyme from brain, at pH 8.0 and 30°C | Rattus norvegicus | sildenafil | |
| 0.00267 | - |
enzyme from peritoneal macrophage, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
| 0.00301 | - |
enzyme from L1210 cells, at pH 8.0 and 30°C | Mus musculus | sildenafil | |
| 0.00332 | - |
enzyme from RAW264.7 cells, at pH 8.0 and 30°C | Mus musculus | sildenafil | |
| 0.00436 | - |
enzyme from peritoneal macrophage, at pH 8.0 and 30°C | Mus musculus | sildenafil | |
| 0.00475 | - |
enzyme from brain, at pH 8.0 and 30°C | Rattus norvegicus | carboxyamidotriazole | |
| 0.00705 | - |
enzyme from RAW264.7 cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
| 0.00898 | - |
enzyme from Lewis lung carcinoma cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
| 0.0115 | - |
enzyme from L1210 cells, at pH 8.0 and 30°C | Mus musculus | carboxyamidotriazole | |
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