Cloned (Comment) | Organism |
---|---|
expression of PDE isoenzymes PDEA1, PDEA2 and PDEA3 in COS-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | - |
Homo sapiens | |
zaprinast | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0058 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
0.006 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
0.0062 | - |
cGMP | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | Homo sapiens | - |
guanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoenzymes PDE5A1, PDE5A2 and PDE5A3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | - |
Homo sapiens | - |
corpus cavernosum | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
smooth muscle | smooth muscle specific expression of PDE5A3 | Homo sapiens | - |
urethra | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | guanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGMP-binding cGMP-specific phosphodiesterase | - |
Homo sapiens |
PDE5 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000013 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
0.000014 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
0.000028 | - |
sildenafil | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens | |
0.0013 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A2 | Homo sapiens | |
0.0016 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A3 | Homo sapiens | |
0.0032 | - |
zaprinast | 37°C, pH 7.4, recombinant isoenzyme PDE5A1 | Homo sapiens |