KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
cGMP | isoform PDE3, 22°C, pH 7.0 | Dictyostelium discoideum | |
0.00075 | - |
cAMP | isoform PDE1, 22°C, pH 7.0 | Dictyostelium discoideum | |
0.005 | - |
cAMP | isoform PDE2, 22°C, pH 7.0 | Dictyostelium discoideum | |
0.0125 | - |
cAMP | isoform PDE7, 22°C, pH 7.0 | Dictyostelium discoideum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
isoforms PDE1, PDE2, PDE3, PDE7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cAMP + H2O | degradation of extracellular cAMP by isoforms PDE1, PDE7. Degradation of intracellular cAMP by isoform PDE2 | Dictyostelium discoideum | 5'-AMP | - |
? | |
cGMP + H2O | degradation of intracellular cGMP by isoform PDE3 | Dictyostelium discoideum | 5'-GMP | - |
? | |
additional information | isoforms PDE1 and PDE7 are dual-specificity enzymes with negative cooperativity and very different kinetics. Both have 2-3fold lower affinity for cGMP than for cAMP | Dictyostelium discoideum | ? | - |
? |