Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | IC50 for vardenafil, sildenafil and tadalafil is above 10000 nM, PDE2 | Homo sapiens | |
sildenafil | IC50: 1725 nM, PDE11; IC50: 350 nM, PDE1 | Homo sapiens | |
tadalafil | IC50: 67 nM, PDE11; IC50: above 10000 nM, PDE1 | Homo sapiens | |
vardenafil | IC50: 121 nM, PDE1; IC50: 308 nM, PDE11 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
PDE1 | - |
Homo sapiens | - |
PDE11 | - |
Homo sapiens | - |
PDE2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | PDE2 | Homo sapiens | - |
brain | PDE1 | Homo sapiens | - |
brain | PDE2 | Homo sapiens | - |
corpus cavernosum | PDE2 | Homo sapiens | - |
heart | PDE1 | Homo sapiens | - |
heart | PDE2 | Homo sapiens | - |
kidney | PDE11 | Homo sapiens | - |
liver | PDE11 | Homo sapiens | - |
pituitary gland | PDE11 | Homo sapiens | - |
prostate gland | PDE11 | Homo sapiens | - |
skeletal muscle | PDE11 | Homo sapiens | - |
testis | PDE11 | Homo sapiens | - |
vascular smooth muscle | PDE1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE11 | Homo sapiens | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE2 | Homo sapiens | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | activity with 3',5'-cGMP is higher than with 3',5'-cAMP | Homo sapiens | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE11 | Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | activity with 3',5'-cGMP and 3',5'-cAMP is nearly identical, PDE2 | Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | activity with 3',5'-cGMP is higher than with 3',5'-cAMP | Homo sapiens | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE1 | - |
Homo sapiens |
PDE11 | - |
Homo sapiens |
PDE2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000067 | - |
IC50: 67 nM, PDE11 | Homo sapiens | tadalafil | |
0.000121 | - |
IC50: 121 nM, PDE1 | Homo sapiens | vardenafil | |
0.000308 | - |
IC50: 308 nM, PDE11 | Homo sapiens | vardenafil | |
0.00035 | - |
IC50: 350 nM, PDE1 | Homo sapiens | sildenafil | |
0.001725 | - |
IC50: 1725 nM, PDE11 | Homo sapiens | sildenafil | |
0.01 | - |
IC50 for vardenafil, sildenafil and tadalafil is above 10000 nM, PDE2 | Homo sapiens | additional information | |
0.01 | - |
IC50: above 10000 nM, PDE1 | Homo sapiens | tadalafil |