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Literature summary for 3.1.4.11 extracted from

  • Sala, G.; Dituri, F.; Raimondi, C.; Previdi, S.; Maffucci, T.; Mazzoletti, M.; Rossi, C.; Iezzi, M.; Lattanzio, R.; Piantelli, M.; Iacobelli, S.; Broggini, M.; Falasca, M.
    Phospholipase Cgamma1 is required for metastasis development and progression (2008), Cancer Res., 68, 10187-10196.
    View publication on PubMed
Search for more literature for 3.1.4.11

Application

Application Comment Organism
drug development PLCgamma1 inhibitors may have potential therapeutic applications for the clinical treatment of tumor metastasis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information experimental metastasis assays with tetracycline in nude mice show that inducible knockdown of PLCgamma1 strongly inhibits development of MDA-MB-231-derived lung metastasis and reverts metastasis formation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 breast cancer patients
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
lymph node metastases Homo sapiens
-
MDA-MB-231 cell pSuperior 3Mut and pSuperior shPLCgamma1 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-
TSA cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
phospholipase Cgamma1
-
 Homo sapiens
PLCgamma1
-
 Homo sapiens