Protein Variants | Comment | Organism |
---|---|---|
additional information | cells carrying either of two different deletion-insertion mutations, plcIDELTA1::HIS3 and plcDELTA2::LEU2, are viable but display several distinctive phenotypes, including temperature-sensitive growth, inviable above 35°C, osmotic sensitivity and defects in utilization of galactose, raffinose and glycerol at permissive temperatures, 23°C to 30°C | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100600 | - |
x * 100600, calculation from nucleotide sequence | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 4,5-bisphosphate + H2O | Saccharomyces cerevisiae | the enzyme generates two second messengers: D-myo-inositol 1,4,5-trisphosphate and diacylglycerol | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol + H2O | Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively | Saccharomyces cerevisiae | ? | - |
? | |
phosphatidylinositol 4,5-bisphosphate + H2O | - |
Saccharomyces cerevisiae | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | Ca2+ required. At 0.1 mM the enzyme hydrolyzes phosphatidylinositol 4,5-diphosphate at faster rate than phosphatidylinositol, at 0.005 mM Ca2+ it hydrolyzes phosphatidylinositol 4,5-diphosphate exclusively | ? | |
phosphatidylinositol 4,5-bisphosphate + H2O | the enzyme generates two second messengers: D-myo-inositol 1,4,5-trisphosphate and diacylglycerol | Saccharomyces cerevisiae | D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 100600, calculation from nucleotide sequence | Saccharomyces cerevisiae |