Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | maximal effect around 2 mM | Rattus norvegicus | |
Mg2+ | maximal effect around 2 mM | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADPgammaS | - |
Rattus norvegicus | |
alpha,beta-methylene-ADP | - |
Rattus norvegicus | |
AMP | - |
Rattus norvegicus | |
ATP | - |
Rattus norvegicus | |
ATPgammaS | - |
Rattus norvegicus | |
beta,gamma-methylene-ATP | - |
Rattus norvegicus | |
diadenosine polyphosphate | competitive | Rattus norvegicus | |
diethyl dicarbonate | - |
Rattus norvegicus | |
EDTA | drastic reduction of activity | Rattus norvegicus | |
heparin | competitive | Rattus norvegicus | |
suramin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Rattus norvegicus | 5886 | - |
synaptosome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required for reactivation of enzyme after treatment with EDTA | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Renatured (Comment) | Organism |
---|---|
reactivation of enzyme after treatment with EDTA requires Zn2+ | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | no difference in enzyme activity between young and adult animals | Rattus norvegicus | - |
central nervous system | - |
Rattus norvegicus | - |
cerebellum | highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus | Rattus norvegicus | - |
hippocampus | highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus | Rattus norvegicus | - |
hypothalamus | highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diethenoadenosine polyphosphate + H2O | - |
Rattus norvegicus | ethenoadenosine 5'-monophosphate + ethenoadenosine (n-1)5'-polyphosphate | - |
? | |
additional information | isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain | Rattus norvegicus | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | - |
Rattus norvegicus |