Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.95 extracted from

  • St-Denis, N.; Gupta, G.D.; Lin, Z.Y.; Gonzalez-Badillo, B.; Pelletier, L.; Gingras, A.C.
    Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission (2015), Mol. Cell. Proteomics, 14, 946-960 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.95

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
133000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O Homo sapiens
-
 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
M2-FLAG magnetic bead chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
MTMR3
-
 Homo sapiens
MTMR4
-
 Homo sapiens
myotubularin-related protein 3
-
 Homo sapiens
myotubularin-related protein 4
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction both depletion and overexpression of either myotubularin-related protein 3 or myotubularin-related protein 4 results in abnormal midbody morphology and cytokinesis failure Homo sapiens
physiological function myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55000 Da to ensure proper abscission Homo sapiens