Literature summary for 3.1.3.95 extracted from

Tronchere, H.; Laporte, J.; Pendaries, C.; Chaussade, C.; Liaubet, L.; Pirola, L.; Mandel, J.L.; Payrastre, B.
Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells (2004), J. Biol. Chem., 279, 7304-7312.

Search for more literature for 3.1.3.95

Application

Application	Comment	Organism
medicine	mutations in the MTM1 gene are associated with theX-linked myotubular myopathy	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C375S	complete loss of activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13496	isoform MTM1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O	-	Homo sapiens	1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate	isoform MTM1 can hydrolyze phosphatidylinositol 3,5-bisphosphate both in vitro and in mammalian cells	?
additional information	isoform MTM1 additionally hydrolyzes 1-phosphatidyl-1D-myo-inositol 3-phosphate, reaction of EC 3.1.3.64	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MTM1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	in L6 myotubes overexpressing isoform MTM1, hyperosmotic shock induces an increase in the mass level of 1-phosphatidyl-1D-myo-inositol 5-phosphate that is reduced by 50% upon overexpression of the MTM1 inactive mutant D278A	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)