Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose | induces the expression of G-6-Pase at transcriptional and posttranscriptional levels, strongly increases endogenous G-6-Pase mRNA levels in 832/13 cells and in rat pancreatic islets. Induced levels from islets are still markedly lower than in untreated primary hepatocytes | Rattus norvegicus | |
additional information | distinct cis-regulatory promoter elements are involved in the glucose response of the rat G-6-Pase gene. Full-length (-4078/+64) promoter confers a moderate glucose response to a reporter construct in HL1C rat hepatoma cells, which is dependent on coexpression of glucokinase. The same construct provides a robust glucose response in 832/13 INS-1 rat insulinoma cells, which are not glucogenic | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | expression of dominant-negative versions of both cAMP response element-binding protein and CAAT/enhancer-binding protein blocks the glucose response of the proximal region in a dose-dependent manner | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL1C cell | - |
Rattus norvegicus | - |
INS-1 823/13 cell | - |
Rattus norvegicus | - |
pancreatic islet | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + H2O | - |
Rattus norvegicus | D-glucose + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G-6-Pase | - |
Rattus norvegicus |
glucose-6-phosphatase | - |
Rattus norvegicus |