Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8R2H9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | expressed by active alveolar bone osteoblasts and cementoblasts during cellular cementum formation | Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | in Phospho1-/- mice, acellular cementum formation and mineralization are unaffected, whereas cellular cementum deposition increases despite delayed mineralization and cementoid. Phospho1-/- mice feature disturbances in alveolar bone mineralization. Parallel to other skeletal sites, deposition of mineral-regulating protein osteopontin is increased in alveolar bone in Phospho1-/- mice. Genetic ablation of Spp1, the gene encoding osteopontin, does not ameliorate dentoalveolar defects in Phospho1-/- mice | Mus musculus |