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Literature summary for 3.1.3.75 extracted from
- PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures (2011), Bone, 48, 1066-1074.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of phospho1-R74X-null mutant, i.e. Phospho1-/-, mice by N-ethyl-N-nitrosourea mutagenesis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q8R2H9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| tibia | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PHOSPHO1 | - |
Mus musculus |
| phosphoethanolamine/phosphocholine phosphatase | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | long bones from Phospho1-/- mice do not fracture during 3-point bending but deform plastically. With dynamic loading nanoindentation the elastic modulus and hardness of Phospho1-/- tibiae are significantly lower than wild-type tibia. Mutant mice show significantly lower mineral:matrix ratios and lower carbonate substitutions in Phospho1-/- tibia, phenotype, overview | Mus musculus |
| physiological function | PHOSPHO1 is a phosphoethanolamine/phosphocholine phosphatase involved in the generation of inorganic phosphate for bone mineralization | Mus musculus |
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Release 2023.1 (January 2023)
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