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Literature summary for 3.1.3.74 extracted from

  • Kim, J.E.; Kim, Y.J.; Lee, D.S.; Kim, J.Y.; Ko, A.R.; Hyun, H.W.; Kim, M.J.; Kang, T.C.
    PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins (2016), Sci. Rep., 6, 26576 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q96GD0
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Synonyms

Synonyms Comment Organism
PLPP/CIN
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 Homo sapiens

General Information

General Information Comment Organism
physiological function PDXP transgenic mice have immature spines with small heads, while PDXP knockout mice have gigantic spines. PDXP transgenic mice exhibit enhanced synaptic plasticity, while knockout mice show abnormal synaptic plasticity. PDXP also enhances N-methyl-D-aspartate receptor (GluN) functionality by regulating the coupling of GluN2A with interacting proteins, particularly postsynaptic density-95 Homo sapiens