Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | myotubularin-related protein 6 is activated up to 28fold in the presence of phosphatidylserine liposomes, myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 and assayed in phosphatidylserine liposomes increases 84fold | Homo sapiens | |
myotubularin-related protein 9 | myotubularin-related protein 9 increases the binding of myotubularin-related protein 6 to phospholipids without changing the lipid binding profile, myotubularin-related protein 9 increases the 3-phosphatase activity of myotubularin-related protein 6 up to 6fold, myotubularin-related protein 9 potentiates the effects of myotubularin-related protein 6 on apoptosis | Homo sapiens | |
phosphatidylinositol 4-phosphate | phosphatidylinositol 4-phosphate increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine | Homo sapiens | |
phosphatidylinositol 5-phosphate | allosteric activator, phosphatidylinositol 5-phosphate and increases myotubularin-related protein 6 activity in the presence of myotubularin-related protein 9 in 100% phosphatidylserine | Homo sapiens | |
phosphatidylserine | myotubularin-related protein 6 activity increases 1.8fold in both 50% and 100% phosphatidylserine | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells, HEK-293 TRex cells, and in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in the presence of myotubularin-related protein 9 , both phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate have an inhibitory effect on myotubularin-related protein 6 activity in 50% phosphatidylserine, the 3-phosphatase activity decreases 30 and 40% for phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate, respectively | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
115000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
anti-FLAG affinity column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 3-phosphate + H2O | - |
Homo sapiens | phosphatidylinositol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MTM6 | - |
Homo sapiens |
myotubularin-related protein 6 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Homo sapiens |