Literature summary for 3.1.3.56 extracted from

Mills, S.J.; Dozol, H.; Vandeput, F.; Backers, K.; Woodman, T.; Erneux, C.; Spiess, B.; Potter, B.V.
3-hydroxybenzene 1,2,4-trisphosphate, a novel second messenger mimic and unusual substrate for type-I myo-inositol 1,4,5-trisphosphate 5-phosphatase: Synthesis and physicochemistry (2006), Chembiochem, 7, 1696-1706.

Search for more literature for 3.1.3.56

Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-dihydroxybenzene 1,4-bisphosphate	-	Homo sapiens
benzene 1,2,4-trisphosphate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,3,4-trisphosphate + phosphate	-	?
1D-myo-inositol 1,4,5-trisphosphate + H2O	-	Homo sapiens	1D-myo-inositol 1,4-disphosphate + phosphate	-	?
3-hydroxybenzene 1,2,4-trisphosphate + H2O	this is the first example of its kind to illustrate that an unnatural aromatic polyphosphorylated molecule can be specifically dephosphorylated by type I Ins(1,4,5)P3 5-phosphatase. No reaction with benzene 1,2,4-trisphosphate	Homo sapiens	2,3-dihydroxybenzene 1,4-bisphosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
InsP3 5-phosphatase	-	Homo sapiens
myo-Inositol 1,4,5-trisphosphate 5-phosphatase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.014	-	in the presence of 1 mM Ins-(1,4,5)P3 as substrate	Homo sapiens	benzene 1,2,4-trisphosphate
0.021	-	in the presence of 1 mM Ins-(1,4,5)P3 as substrate	Homo sapiens	2,3-dihydroxybenzene 1,4-bisphosphate

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)