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Literature summary for 3.1.3.43 extracted from
- Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity (2003), Biochim. Biophys. Acta, 1652, 126-135.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | for isozyme PDP1c, simultaneous presence of Ca2+ and E2 component of substrate is required | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
recombinant enzyme | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| [pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate | mechanism, difference in specificity of isoforms | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | different conditions for binding of isoforms to substrate, both isoforms can dephosphorylate all three phosphorylation sites of substrate in a random mechanism | Rattus norvegicus | ? | - |
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