Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine 1-phosphate + H2O | Homo sapiens | - |
sphingosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
U-118MG cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 38000-40000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase-3 | - |
Homo sapiens |
LPP3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lipid phosphate phosphatase-3-knockdown inhibits both U-87 and U-118 glioblastoma cell proliferation in culture and tumor growth in xenograft assays. Lipid phosphate phosphatase-3-knockdown reduces beta-catenin, cyclin-D1, and CD133 expression, with a concomitant increase in phosphorylated beta-catenin | Homo sapiens |
physiological function | forced expression of lipid phosphate phosphatase-3 in human colon tumor (SW-480) cells potentiates tumor growth via increased beta-catenin stability and cyclin-D1 synthesis. Elevated expression of lipid phosphate phosphatase-3 has no tumorigenic effects on primary cells. Lipid phosphate phosphatase-3 regulates glioblastoma cell migration | Homo sapiens |