Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, is rapidly and reversibly activated by strong depolarization of the membrane potential | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C392S | site-directed mutagenesis, inactivating mutation in the conserved CX5R(T/S) motif of the Sac domain | Homo sapiens |
C641A | site-directed mutagenesis, the mutation removes the prenylation site of the enzyme | Homo sapiens |
D556A | site-directed mutagenesis, inactivating point mutation of the conserved DRVL motif of INPP5E | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | voltage-sensitive phosphoinositide phosphatase Ci-VSP | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, removes phosphatidylinositol-4,5-bisphosphate from the plasma membrane | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRR6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | the voltage-sensitive phosphoinositide phosphatase Ci-VSP, a membrane-resident PI(4,5) P2-5-phosphatase, removes phosphatidylinositol-4,5-bisphosphate from the plasma membrane | Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ci-VSP | - |
Homo sapiens |
INPP5E 5-phosphatase | - |
Homo sapiens |
phosphoinositide phosphatase | - |
Homo sapiens |
PI(4,5)P2-5'-phosphatase | - |
Homo sapiens |
voltage-sensitive phosphoinositide phosphatase Ci-VSP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | no relevance of phosphatidylinositol-4,5-bisphosphate for the regulation of the specific ion channel type, termed TASK, and no requirement for the enzyme, overview | Homo sapiens |