Literature summary for 3.1.3.21 extracted from

Pahlman, A.K.; Granath, K.; Ansell, R.; Hohmann, S.; Adler, L.
The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress (2001), J. Biol. Chem., 276, 3555-3563.

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Cloned(Commentary)

Cloned (Comment)	Organism
two isogenes are differentially expressed under conditions of osmotic and anaerobic stress and that the expression of gene 1 is under strong influence of protein kinase A activity	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	mutants lacking both GPP1 and GPP2 isogenes are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol, exhibit strong osmosensitivity, and arrest growth when shifted to anaerobic conditions	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glycerol-3-phosphate + H2O	Saccharomyces cerevisiae	the enzyme is required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress	glycerol + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glycerol-3-phosphate + H2O	-	Saccharomyces cerevisiae	glycerol + phosphate	-	?
glycerol-3-phosphate + H2O	the enzyme is required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress	Saccharomyces cerevisiae	glycerol + phosphate	-	?

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Release 2023.1 (January 2023)