Activating Compound | Comment | Organism | Structure |
---|---|---|---|
nuclear inhibitor of protein phosphatase-1 | NIPP1 directs PP1 to dephosphorylate the U2 small nuclear ribonucleoprotein particle component, spliceosome-associated protein 155, Sap155 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PP1 overexpression compromises pre-mRNA splicing | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C-terminally truncated nuclear inhibitor of protein phosphatase-1 | C-terminally truncated NIPP1 forms a hyperactive holoenzyme with PP1, rendering PP1 minimally phosphorylated on an inhibitory site | Homo sapiens | |
additional information | phosphorylation by cyclin-dependent kinases lower PP1 activity in vitro and vivo | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated spliceosome-associated protein 155 + H2O | Homo sapiens | i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component. nuclear inhibitor of PP1, i.e. NIPP1, a major PP1 interactor in the vertebrate nucleus, recruits PP1 to Sap155 | spliceosome-associated protein 155 + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation by cyclin-dependent kinases lower PP1 activity in vitro and vivo | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated spliceosome-associated protein 155 + H2O | i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component. nuclear inhibitor of PP1, i.e. NIPP1, a major PP1 interactor in the vertebrate nucleus, recruits PP1 to Sap155 | Homo sapiens | spliceosome-associated protein 155 + phosphate | - |
? | |
phosphorylated spliceosome-associated protein 155 + H2O | i.e. Sap155, a U2 small nuclear ribonucleoprotein particle component | Homo sapiens | spliceosome-associated protein 155 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PP1 | - |
Homo sapiens |
protein phosphatase-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PP1 phosphorylation is essential for proper cell cycle progression. NIPP1-associated PP1 regulates Sap155 phosphorylation, overview | Homo sapiens |