Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.16 extracted from

  • Cheng, L.Y.; Wang, J.Z.; Gong, C.X.; Pei, J.J.; Zaidi, T.; Grundke-Iqbal, I.; Iqbal, K.
    Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities (2001), Neurochem. Res., 26, 425-438.
    View publication on PubMed
Search for more literature for 3.1.3.16

Inhibitors

Inhibitors Comment Organism Structure
calyculin moderate inhibition at 0.00001 mM Homo sapiens
cantheridin strong inhibition at 0.005 mM Homo sapiens
EGTA moderate inhibition Homo sapiens
NaF moderate inhibition; strong inhibition Homo sapiens
Tartrate moderate inhibition of P11 at 2 mM; strong inhibition Homo sapiens
tetramisole strong inhibition at 2 mM Homo sapiens
Trifluorperazine moderate inhibition; strong inhibition; strong inhibition at 0.1 mM Homo sapiens
vanadate at 1 mM inhibition to 60% of its activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Co2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens
Mg2+ better activator than Mn2+ Homo sapiens
Mn2+
-
 Homo sapiens
Mn2+ better activator than Mg2+ Homo sapiens
Ni2+
-
 Homo sapiens
Ni2+ best activator Homo sapiens
Ni2+ best activator for P5 Homo sapiens
Zn2+
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 gel filtration Homo sapiens
49000
-
 gel filtration Homo sapiens
90000
-
 gel filtration Homo sapiens
150000
-
 gel filtration Homo sapiens
165000
-
 gel filtration Homo sapiens
250000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.5
-
 with phosphorylase kinase as substrate Homo sapiens
2
-
 with phosphorylase kinase as substrate Homo sapiens
3
-
 with phosphorylase kinase as substrate Homo sapiens
3 8 with p-nitrophenylphosphate as substrate Homo sapiens
4
-
 with phosphorylase kinase as substrate Homo sapiens
8
-
 with phosphorylase kinase as substrate Homo sapiens
11
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
14
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
16
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
19
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
40
-
 with p-nitrophenyl phosphate as substrate Homo sapiens
310
-
 with p-nitrophenyl phosphate as substrate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?
phosphorylated AD P-Tau + H2O
-
 Homo sapiens AD P-Tau + phosphate
-
 ?
phosphorylated phosphorylase kinase + H2O
-
 Homo sapiens phosphorylase kinase + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
P10
-
 Homo sapiens
P11
-
 Homo sapiens
P5
-
 Homo sapiens
P6
-
 Homo sapiens
P7
-
 Homo sapiens
P8
-
 Homo sapiens
P9
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 biphasic pH-optimum at pH 7.5 and 8.5 with Mn2+ as activator Homo sapiens
7
-
 with Mg2+ as activator Homo sapiens
7.5
-
 with Mn2+ as activator Homo sapiens
7.5 8.5 with Mn2+ as activator Homo sapiens
7.5 8 with Mg2+ as activator Homo sapiens
8.5
-
 with Mg2+ as activator Homo sapiens
8.5
-
 with Mn2+ as activator Homo sapiens
10
-
 with Mg2+ as activator Homo sapiens