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Literature summary for 3.1.3.11 extracted from
- Fructose-1,6-diphosphatase from rabbit liver (1975), Methods Enzymol., 42C, 354-359.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activation | Oryctolagus cuniculus |  |
| His | activation | Oryctolagus cuniculus | |
| oleate | activates | Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | - |
Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
4 * 36000, SDS-PAGE | Oryctolagus cuniculus |
| 144000 | - |
- |
Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | proteolytic digestion converts the neutral enzyme form, AMP sensitive, to an alkaline form, AMP insensitive, with pH-optimum at 9.0-9.2 | Oryctolagus cuniculus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 14.6 | - |
- |
Oryctolagus cuniculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 2-4°C, stable for several months | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-diphosphate + H2O | - |
Oryctolagus cuniculus | D-fructose 6-phosphate + phosphate | - |
? | |
| sedoheptulose 1,7-bisphosphate + H2O | - |
Oryctolagus cuniculus | sedoheptulose 7-phosphate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 36000, SDS-PAGE | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
proteolytic digestion converts the neutral enzyme form, AMP sensitive, to an alkaline form, AMP insensitive, with pH-optimum at 9.0-9.2 | Oryctolagus cuniculus |
| 7.2 | 7.3 | at 0.1 mM EDTA | Oryctolagus cuniculus |
| 7.6 | 7.8 | above 1 mM Mg2+ | Oryctolagus cuniculus |
| 8.2 | 8.5 | at 1 mM Mg2+ | Oryctolagus cuniculus |
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