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Literature summary for 3.1.26.13 extracted from
- 3-Hydroxypyrimidine-2,4-diones as selective active site inhibitors of HIV reverse transcriptase-associated RNase H design, synthesis, and biochemical evaluations (2016), J. Med. Chem., 59, 2648-2659 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-hydroxy-4-[4-(quinolin-3-yl)anilino]pyrido[2,3-d]pyrimidin-2(1H)-one | - |
Human immunodeficiency virus 1 |  |
| 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 3-(benzyloxy)-6-((2'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((3-(pyrimidin-5-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((3-(tetrahydrofuran-3-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-oxy)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-amino)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-oxy)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-1-methyl-6-(4-(pyridin-4-yl)phenoxy)pyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 3-hydroxy-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',4'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((2-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3',5'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-[1,1'-biphenyl]-2-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-chloro-[1,1'-biphenyl]-4-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4'-fluoro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-((4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-2-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-3-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-3-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-4-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| 6-([1,1'-biphenyl]-4-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | - |
Human immunodeficiency virus 1 | |
| additional information | 3-hydroxypyrimidine-2,4-diones act as selective active site inhibitors of HIV reverse transcriptase-associated RNase H, design, synthesis, and biochemical evaluations, overview. No inhibition by 9z. The activity and selectivity profiles of subtype 11 are manifested with a few selected analogues demonstrating exceptional potency in inhibiting RNase H. Although they also inhibit RT pol, the micromolar activity reflects a sizable selectivity (14-49 fold) strongly favoring RNase H inhibition. The compounds also show inhibition of integrase strand transfer (INST) activity. Molecular modelling | Human immunodeficiency virus 1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
HIV-1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| HTS-1 + H2O | RNA/DNA duplex substrate HTS-1 (RNA 5'-gaucugagccuggagcu-3'-fluorescein annealed to DNA 3'-CTAGACTCGGACCCTCGA-5'-dabsyl) is a high sensitivity duplex that assesses non-specific internal cleavage | Human immunodeficiency virus 1 | ? | - |
? | |
| HTS-2 + H2O | HTS-2 (RNA 5'-cugguuagaccagaucugagccugggagcu-3'-fluorescein annealed to DNA 3'-GGTCTAGACTCGGACCCTCGA-5'-dabsyl) provides a duplex with a recessed DNA 3'-terminus and measures 3'-DNA directed or polymerase directed RNase H cleavage | Human immunodeficiency virus 1 | ? | - |
? | |
| HTS-3 + H2O | HTS-3 (RNA 5'-accagaucugagccugggagcu-3'-fluorescein annealed to DNA 3'-GACCAATCTGGTCTAGACTCGGACCCTCGA-5'-dabsyl) measures 5'-RNA-directed RNase H cleavage | Human immunodeficiency virus 1 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HIV reverse transcriptase-associated RNase H | - |
Human immunodeficiency virus 1 |
| HIV RNase H | - |
Human immunodeficiency virus 1 |
| HIV RT-associated RNase H | - |
Human immunodeficiency virus 1 |
| human immunodeficiency virus reverse transcriptase-associated RNase H | - |
Human immunodeficiency virus 1 |
| human immunodeficiency virus RT-associated RNase H | - |
Human immunodeficiency virus 1 |
| RT RNase H | - |
Human immunodeficiency virus 1 |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00015 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.00018 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00019 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0002 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0002 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-fluoro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00022 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00022 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00024 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00025 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.00025 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.00025 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.00025 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0003 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0003 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-fluoro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0003 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0003 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-fluoro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00031 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00032 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00037 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00037 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00038 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0004 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0004 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0004 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0004 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.00043 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00044 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.00045 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.00045 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00045 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00046 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00047 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00047 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00049 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0005 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0005 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0005 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.00051 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00054 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0006 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0006 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0006 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.00066 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0007 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0007 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0007 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0007 | - |
enzyme activity reaction with substrates HTS-1-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 1-hydroxy-4-[4-(quinolin-3-yl)anilino]pyrido[2,3-d]pyrimidin-2(1H)-one | |
| 0.00075 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0008 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0008 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.00085 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-3-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0009 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0009 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.001 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.001 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.001 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-3-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0011 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0011 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0012 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0012 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0012 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0013 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0014 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((3-(pyrimidin-5-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0015 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0016 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0016 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0016 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0017 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0019 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0019 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0019 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.002 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0021 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0021 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0022 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0022 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0023 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0023 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0024 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-4-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0024 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione | |
| 0.0025 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0025 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0026 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0026 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0027 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0027 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0028 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0028 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0028 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.003 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0031 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0032 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0033 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-2-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0033 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0034 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0034 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-3-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0035 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0035 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0035 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0035 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-3-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0035 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0036 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0037 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-(4-(pyridin-4-yl)phenoxy)pyrimidine-2,4-(1H,3H)-dione | |
| 0.0037 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0037 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0038 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0038 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0038 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0039 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0039 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0039 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((3-(pyrimidin-5-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.004 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.004 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0041 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((3-(pyrimidin-5-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0041 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0042 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0043 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0043 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0043 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0044 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0045 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0046 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0047 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-2-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0047 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0047 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.005 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0051 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0051 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0053 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0053 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',4'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0057 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.006 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-([1,1'-biphenyl]-4-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione | |
| 0.0062 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-oxy)pyrimidine-2,4(1H,3H)-dione | |
| 0.0062 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0066 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0066 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0066 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0066 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0067 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.0069 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.0069 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0072 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione | |
| 0.0072 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0081 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-(benzyloxy)-6-((2'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0089 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-amino)pyrimidine-2,4(1H,3H)-dione | |
| 0.0089 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0092 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0093 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0094 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.0095 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-oxy)pyrimidine-2,4(1H,3H)-dione | |
| 0.01 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-1-methyl-6-(4-(pyridin-4-yl)phenoxy)pyrimidine-2,4-(1H,3H)-dione | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.011 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-4-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.012 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.012 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.013 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile | |
| 0.013 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.013 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-((4'-chloro-[1,1'-biphenyl]-2-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.015 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.016 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.016 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.017 | - |
enzyme activity reaction with substrate HTS-2, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.021 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.022 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
| 0.022 | - |
enzyme activity reaction with substrate HTS-3, pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione | |
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